Current Research
Coming soon!
Past Research Projects
Dynamics of Gene Families in the Evolution of Termite Eusociality
As part of an international genome project, I used a variety of comparative genomics methods to investigate the evolution of eusociality in termites. My main focus was the evolution of gene families. To this end, I clustered 19 insect proteomes into gene families and modelled family evolution across the phylogeny. I found many families related to chemoperception, immunity and diet that showed a significant size change in termites. My results contributed to our recent publication in Nature Ecology & Evolution.
Development of a Proteome Quality Assessment Tool
I developed the prototype of DOGMA, a Python tool that assesses the quality of proteomes and transcriptomes. This is achieved by finding highly conserved protein domains and domain arrangements that occur in all eukaryotic model organisms. DOGMA screens a given proteome or transcriptome for this set to estimate its completeness. My prototype was further developed by Elias Dohmen. DOGMA is available online and published in Bioinformatics. The DOGMA-scores of over 3,200 proteomes are now available on the Proteome Quality Index website.
Development of a Python Library for Computational Proteomics
In a team of five, I developed Ursgal, a Python library that offers a scriptable interface to common bottom-up proteomics tools such as peptide search engines and statistical post-processing tools. This facilitates the development of custom proteomics workflows in a few lines of code. Ursgal is freely available on GitHub and published in the Journal of Proteome Research.
Publications
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Mark C Harrison, Nicolas Arning, Lukas PM Kremer (…) Maria-Dolors Piulachs, Stephen Richards, Coby Schal:
Expansions of key protein families in the German cockroach explain the remarkable success of this global indoor pest
JEZ-B: Molecular and Developmental Evolution, 2018 -
Lukas PM Kremer, Judith Korb and Erich Bornberg-Bauer:
Reconstructed Evolution of Insulin Receptors in Insects Reveals Duplications in Early Insects and Cockroaches
JEZ-B: Molecular and Developmental Evolution, 2018 -
Mark C Harrison, Evelien Jongepier, Hugh M Robertson, (…) Lukas PM Kremer (…) Xavier Belles, Judith Korb and Erich Bornberg-Bauer:
Hemimetabolous genomes reveal molecular basis of termite eusociality
Nature Ecology and Evolution, 2017 -
Daniel Elsner, Lukas PM Kremer, Nicolas Arning and Erich Bornberg-Bauer:
Comparative genomic approaches to investigate molecular traits specific to social insects
Current Opinion in Insect Science, 2016 -
Elias Dohmen, Lukas PM Kremer, Erich Bornberg-Bauer and Carsten Kemena:
DOGMA: Domain-based transcriptome and proteome quality assessment
Bioinformatics, 2016 -
Lukas PM Kremer, Johannes Leufken, Purevdulam Oyunchimeg, Stefan Schulze and Christian Fufezan:
Ursgal: Universal Python Module Combining Common Bottom-Up Proteomics Tools for Large-Scale Analysis
Journal of Proteome Research, 2015
Publication Profiles: